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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
05/07/2023 |
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Data da última atualização: |
15/01/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TEODORO, K. B. R.; ALVARENGA, A. D.; OLIVEIRA, L. F. R.; CHAGAS, P. A. M.; LOPES. R. G.; ANDRE, R. S.; MERCANTE, L. A.; ALVES, F.; STRINGASCI, M. D.; BUZZA, H. H.; INADA, N. M.; CORREA, D. S. |
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Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Fast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
ACS Applied Bio Materials, v. 6, 2023. |
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Páginas: |
2325–2337 |
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DOI: |
https://doi.org/10.1021/acsabm.3c00177 |
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Idioma: |
Inglês |
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Conteúdo: |
herapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds. Menosherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different enviro... Mostrar Tudo |
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Palavras-Chave: |
Natural dye; Optical sensor; Photodynamic therapy; Solution blow spinning; Wound dressing. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03154naa a2200337 a 4500
001 2154815
005 2024-01-15
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsabm.3c00177$2DOI
100 1 $aTEODORO, K. B. R.
245 $aFast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings.$h[electronic resource]
260 $c2023
300 $a2325–2337
520 $aherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds.
653 $aNatural dye
653 $aOptical sensor
653 $aPhotodynamic therapy
653 $aSolution blow spinning
653 $aWound dressing
700 1 $aALVARENGA, A. D.
700 1 $aOLIVEIRA, L. F. R.
700 1 $aCHAGAS, P. A. M.
700 1 $aLOPES. R. G.
700 1 $aANDRE, R. S.
700 1 $aMERCANTE, L. A.
700 1 $aALVES, F.
700 1 $aSTRINGASCI, M. D.
700 1 $aBUZZA, H. H.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
773 $tACS Applied Bio Materials$gv. 6, 2023.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Recursos Genéticos e Biotecnologia. Para informações adicionais entre em contato com cenargen.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
11/02/1998 |
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Data da última atualização: |
03/09/2014 |
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Autoria: |
BATISTA, M. de F.; FONSECA, J. N. L.; MENDES, M. A. S.; URBEN, A. F.; MANSO, E. S. B. G. C.; TENENTE, R. C. V.; OLIVEIRA, M. R. V. de; GUIMARAES, P. M.; FREITAS, R. D. L.; MARQUES, A. S. dos A. |
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Título: |
Quarentena de germoplasma vegetal. |
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Ano de publicação: |
1998 |
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Fonte/Imprenta: |
Brasilia: Embrapa-Cenargen, 1998 |
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Páginas: |
11p. |
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Série: |
(Embrapa-Cenargen. Comunicado Tecnico, 27). |
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Idioma: |
Português |
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Conteúdo: |
Introdução; Introduções inadvertidas de pragas em espécies vegetais; Importância da quarentena; Legislação; Procedimento para o intercambio de germoplasma vegetal; Procedimentos para o intercambio de materiais vegetais destinados ao comercio; Procedimento quarentenarios realizados em germoplasma vegetal; Inspeção ao ponto de ingresso do germoplasma; Quarentena em germoplasma vegetal no Cenargen; Fitopatologia; Tratamento para erradicação de patogenos; Pragas de importância quarentenaria para o Brasil; Análise de risco de praga; Pragas exoticas interceptadas pela Embrapa-Cenargen. |
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Palavras-Chave: |
Brasil; Brasilia; Change; Controle; Doenca da planta; Germoplasma vegetal; Intercambio; Legislation; Pest insects; Plant diseases; Plants; Quarentine; Vegetal. |
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Thesagro: |
Germoplasma; Legislação; Planta; Praga; Praga de Planta; Quarentena. |
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Thesaurus NAL: |
germplasm; quarantine. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01834nam a2200493 a 4500
001 1174468
005 2014-09-03
008 1998 bl uuuu u0uu1 u #d
100 1 $aBATISTA, M. de F.
245 $aQuarentena de germoplasma vegetal.
260 $aBrasilia: Embrapa-Cenargen$c1998
300 $a11p.
490 $a(Embrapa-Cenargen. Comunicado Tecnico, 27).
520 $aIntrodução; Introduções inadvertidas de pragas em espécies vegetais; Importância da quarentena; Legislação; Procedimento para o intercambio de germoplasma vegetal; Procedimentos para o intercambio de materiais vegetais destinados ao comercio; Procedimento quarentenarios realizados em germoplasma vegetal; Inspeção ao ponto de ingresso do germoplasma; Quarentena em germoplasma vegetal no Cenargen; Fitopatologia; Tratamento para erradicação de patogenos; Pragas de importância quarentenaria para o Brasil; Análise de risco de praga; Pragas exoticas interceptadas pela Embrapa-Cenargen.
650 $agermplasm
650 $aquarantine
650 $aGermoplasma
650 $aLegislação
650 $aPlanta
650 $aPraga
650 $aPraga de Planta
650 $aQuarentena
653 $aBrasil
653 $aBrasilia
653 $aChange
653 $aControle
653 $aDoenca da planta
653 $aGermoplasma vegetal
653 $aIntercambio
653 $aLegislation
653 $aPest insects
653 $aPlant diseases
653 $aPlants
653 $aQuarentine
653 $aVegetal
700 1 $aFONSECA, J. N. L.
700 1 $aMENDES, M. A. S.
700 1 $aURBEN, A. F.
700 1 $aMANSO, E. S. B. G. C.
700 1 $aTENENTE, R. C. V.
700 1 $aOLIVEIRA, M. R. V. de
700 1 $aGUIMARAES, P. M.
700 1 $aFREITAS, R. D. L.
700 1 $aMARQUES, A. S. dos A.
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Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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